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The resulting models and Sigma-A weighted 2mFo-DFc electron density maps were inspected to assess if the ligands were still observable before refining ligand occupancy with Buster (Supplementary Fig

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It is not approved by the FDA and is not intended for human or animal consumption, nor for diagnostic, therapeutic, or clinical applications

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The starting dose of 0.3 mg represents approximately 6.7% of the final maintenance dosea conservative approach that prioritizes safety