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Multivesicular body A type of late endosome that is formed following the inward budding of the outer endosomal membrane and characterized by the accumulation of vesicles in the lumen
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Due to CR-induced immune system depletion and mutagenesis/genotoxic events (leading to occurrence and accumulation of a driver mutation and genome instability), the risks of oncogene activation and tumor suppressor depletion required for conversion to tumorinitiating cells over long periods could increase (60)
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