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Oncotarget 7 , 84558465 (2016)

From "Kidneys Govern Bones" to Chronic Kidney Disease, Diabetes Mellitus, and Metabolic Bone Disorder: A Crosstalk between Traditional Chinese Medicine and Modern Science

Additionally, researchers use this formulation in tissue-related research models

In other cases, the cause is unknown (idiopathic), likely from a mix of genes, metabolism, and immune issues

This reaction not only prevents heme-induced cellular sensitization to oxidative stress and apoptosis but also generates metabolites with independent cytoprotective effects