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10.1039/C5CC00981B

The specific functional logic is as follows: In addition to GPR activation, SCFAs (especially butyrate) cross the blood-brain barrier via monocarboxylate transporter 1 (MCT1) and inhibit HDAC1/2 in the hippocampus and prefrontal cortexbrain regions critical for mood regulation

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Mechanism of Action: Why It Makes Sense for Athletes Sermorelin binds to GHRH receptors in the anterior pituitary, increasing pulsatile GH release and downstream insulin-like growth factor-1 (IGF-1) production. Growth hormone and IGF-1 influence several systems relevant to performance: Protein synthesis and muscle repair Collagen formation and tendon remodeling Lipolysis and metabolic efficiency Sleep architecture, particularly slow-wave sleep Because GH secretion is naturally highest during deep sleep, sermorelin is typically administered at night to align with this physiology