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They exhibit significant structural diversity, varying in compactness, the amount of flexible secondary structure they possess, and the number of tertiary contacts they form (Dunker and Obradovic, 2001
doi: 10.1007/s12020-022-03107-7 117
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455 Therefore, sildenafil holds promise as a therapeutic option for HAPH patients, warranting further investigation to address its efficacy and safety
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