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Despite showing clear clinical signs of B12 deficiency, doctors often misdiagnose or ignore these people because their results fall within a good B12 level range

Research (PMID: 11472075) shows this modification substantially reduces binding affinity to IGF-binding proteins (IGFBPs) compared to native IGF-1, resulting in a longer circulating half-life and sustained bioavailability in research models a key reason LR3 variants are used in preference to native IGF-1 in extended-duration studies

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Riemann D, Klein T, Rodenbeck A, et al

Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, et al

10.1016/j.exer.2017.02.016 51 LiH.DengN.HeX.LiY