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Neuronal mitochondria are the target of glutamate, which attenuates succinate dehydrogenase (a key enzyme of the TCA cycle) inhibition by oxaloacetate [63], with further induction of ROS production [64]

Notably, a significant loss of negative co-expression between SNCA and interferon-gamma genes in the substantia nigra has been demonstrated in PD patients as compared to controls 41

[7] The concentration of glutathione in the cytoplasm is significantly higher (ranging from 0.5-10 mM) compared to extracellular fluids (2-20 M), reaching levels up to 1000 times greater

10.1161/01.cir.69.5.1026 19 DiplockA