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Effects in active malignancy are not well characterized, and most clinicians treat this as an exclusion until more data exists

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doi: 10.3389/fmicb.2020.00299

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Results of preclinical and in vitro studies have shown that activation of the IRR requires concentrations of ARA 290 greater than or equal to ~1 nmol/L (~1.3 ng/mL) (14)

Similarly, overly aggressive hair care (frequent colouring, chemical straightening, excessive heat from styling tools) weakens the hair fibre and can eventually damage the follicle