Enhancement of purine nucleotide synthesis via the pentose phosphate pathway was found to be advantageous for cell proliferation and tumorigenesis of NRF2-addicted cancer cells (Mitsuishi et al
Factors that influence the decision include: baseline IGF-1 (lower IGF-1 may favor sermorelin to start), metabolic syndrome status (favors tesamorelin), visceral adiposity (favors tesamorelin), prior response to growth hormone-releasing peptides (helps calibrate dose), and patient tolerance preferences
Zhang Y, Wang L, Zhou X, Geng J, Li X (2019) The immunomodulatory mechanism of brain injury induced by hyperhomocysteinemia in spontaneously hypertensive rats
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a , The number of surviving wild-type cells