Your body will become more susceptible to oxidative stress
Associated variants are on ATP8B1 (responsible for PFIC1 and (B)RIC1) and ABCB11 (determining PFIC2 and (B)RIC2) genes [9], but cases linked to MYO5B variants have also been recently described [60]
Furthermore, ROS-induced oxidative inactivation of PTP1B phosphatase at the Cys215 site exacerbates insulin signaling transduction impairment [344]
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Further studies have established that APR-246 can also trigger p53-independent cell death in several solid cancers, suggesting that besides p53, other cellular targets might be involved in APR-246 effect [56]
It also oxidizes thiol groups of proteins, forming disulfide bonds that alter Bcl-2 family protein conformation and function, disrupting the balance between pro-apoptotic and anti-apoptotic proteins [79]
