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Phosphorylation of Drp1 at Ser637 by Ca 2+ /calmodulin-dependent protein kinase I (CaMKI) and protein kinase A (PKA) has an opposite, inhibitory effect on mitochondrial fission [316, 317]

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Four significant pathways were identified: CRMPs in Sema3A signaling, KEAP1-NFE2L2 pathway, Purinergic signaling in leishmaniasis infection, and Collagen degradation (Fig

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Furthermore, extensive research has demonstrated that EVs can also carry antigens, toxins, and pro-inflammatory cytokines, potentially serving as drivers of inter-organ diseases 154,155,156