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Whole genome CRISPR screen reveals that GPX4 loss increases sensitivity to the ER antagonist and degrader giredestrant Clinically, palbociclib and other CDK4/6 inhibitors are used as standard of care in combination with endocrine therapies

2020;33: e13998

The FDA-approved version (Vyleesi) treats premenopausal HSDD

In terms of the Nrf2/HO-1 signaling pathway, Nrf2 not only inhibits ferroptosis and protects intestinal epithelial cells through the Nrf2-GPx4 signaling pathway but also promotes ferroptosis through the Nrf2/HO-1 pathway

The novel H 2 S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoK ATP channels and reduction of oxidative stress

When combined with peptides such as MOTS-c, SS-31, or NAD+, it offers a comprehensive research model for studying anti-aging mechanisms, mitochondrial protection, and energy system preservation