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496 Conclusion and future directions Lactate is proven to be a key source of circulating carbohydrates that fuels the TCA cycle and promotes energy production in tumors

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The most commonly reported side effects include: Nausea : Affecting 12% to 24% of patients with type 2 diabetes and 24% to 31% in weight management trials Diarrhea : 12% to 17% in diabetes trials and 18% to 23% in weight management trials Decreased appetite : 5% to 10% of patients Vomiting : 5% to 10% in diabetes trials and 8% to 12% in weight management trials Constipation : 5% to 7% in diabetes trials and 16% to 17% in weight management trials Dyspepsia : 5% to 9% of patients Abdominal pain : 5% to 9% of patients Alopecia (hair loss) : Reported in weight management trials These symptoms are typically mild to moderate in severity, occur most commonly during dose escalation, and tend to diminish over time as patients develop tolerance

Over a month, you and your provider can review those to see if the injection is helping

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doi: 10.1515/nf-2022-0016 51 EggermontJ