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May 2018;33(5):561572

[DOI] [PubMed] [Google Scholar] 136.Seifi-Jamadi A, Ahmad E, Ansari M, Kohram H

The peptide undergoes rapid first-pass metabolism when absorbed, which is why bioavailability varies significantly by administration route

The circadian clock protein bmal1 is necessary for fertility and proper testosterone production in mice

Yet its worth noting that a high positive charge does not necessarily indicate a stronger cell-penetrating ability, that is, the two are not in a simple linear relationship, as researchers have shown that peptides with an NC higher than +7 rapidly reduce cellular pathways [168]