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Adding to the complexity, if the viral glycoprotein cross-seeds an endogenous brain protein, years later even the viral protein need not be present, as the run-away proteopathy would now involve only endogenous brain protein (s)

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Year trends in the use of DHTs The use of DHTs in interventional trials for the selected rare diseases first appeared in 2009 and showed a gradual but consistent increase through 2019 (Fig

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