Without enough glutathione, these free radicals can cause oxidative stress, which is essentially biological "rusting" that can damage your cells over time
The appeal makes sense on the surface, naturally occurring, targeted mechanisms, marketed as smarter than traditional pharmaceuticals
Han S, Jeong S, Ahn JC, Cho Y, Choi S, Park SJ, et al
These enzymes are involved in nutrient sensing and the cellular response to stress, including hypoxia, and are implicated in various disease processes (reviewed Fletcher and Coleman, 2020)
For example, insufficient B12 may result in methyl folate not being able to give up its methyl group and it gets stuck in-between the two cycles, with MTR not being able to do its part
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