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Dubois VL, Platel DFN, Pauly G, Tribouleyduret J (1995) Plasmodium berghei : implication of intracellular glutathione and its related enzyme in chloroquine resistance in vivo

The peptide's ability to cross the blood-brain barrier and its stability may make this route viable

This apparent safety in rodents spanning 30+ years of research from multiple independent laboratories is genuine

145 Under oxidative stress, Cys34 thiol shifts to a sulfenic acid (HSA-SOH), which can be irreversibly oxidized to the sulfinic (HSA-SO2H) and sulfonic (HSA-SO3H) acids or, through the reactions with glutathione, can be returned to the HSA-SH reduced form

A., Zaky, H

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