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In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )

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To maximize the benefits, it's important to complement these injections with healthy habits such as a nutritious diet, regular exercise, and adequate rest

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4- 40%-

The increase in GH secretion precedes the reduction in IGF-I levels that is only evident by the third day of fasting, thereby ruling out the increase in GH during fasting is related to reductions in total IGF-I