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These cytokines can negatively impact synaptic plasticity by inhibiting the signaling pathways involved in LTP

Int J Mol Sci 19(12):3894 Johnson AC, Li Z, Orfila JE, Herson PS, Cipolla MJ (2021) Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia

A., Jr (2015)

In obese and insulin-resistant states, neutrophils are among the first leukocytes to infiltrate expanding visceral adipose tissue, where they secrete IL-8, TNF-, and elastase, establishing an early inflammatory niche that recruits monocytes and macrophages [5, 17]

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iv) these mentioned points were also included in the assessment of the rats which only underwent BPC 157 or saline retrobulbar administration