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Copper ions in GHK-Cu can inhibit up to 90% of type 1 5-alpha reductase, potentially reducing DHT-related follicle miniaturization without systemic hormonal effects

The release of HMGB1 can exacerbate cellular damage and inflammation, potentially leading to hepatitis and steatohepatitis [227]

Ltd for supporting this project by providing the necessary facilities

Another major advantage of GHK-Cu it is compatible with most skin types, including sensitive skin

2.5 HPLC analysis of safflower aqueous extract The polyphenols of safflower aqueous extract were determined using the HPLC system at the National Research Center (NRC) in Giza, Egypt, according to UV and diode array detection (DAD) methods (Mizzi et al., 2020)

Additional reagents R,S-Sulforaphane was purchased from LKT Laboratories, Inc