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The 8-oxo-dG adduct in the mitochondrial and nuclear DNA is a pre-mutagenic lesion formed primarily by an attack by the hydroxyl radical ( OH)

Miyata T, Kurokawa K, van Ypersele de Strihou C: Relevance of oxidative and carbonyl stress to long-term uremic complications

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For a contrasting case in which a peptide with a defined endogenous role and a more constrained but still incomplete mechanistic literature has nonetheless attracted sustained research interest, see the epitalon research brief