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Glycine and serine are principal donors of single-carbon units to the one-carbon metabolism cycle, a key metabolic process in the human body that involves folate-mediated movement of single-carbon units for methylation, redox, and biosynthetic reactions 15

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These results imply that exercise stimulates the expression of MOTS-c, which is encoded by mitochondria, in humans (19)

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However, more water means a shorter usable window if you are drawing large volumes relative to the total solution