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This size range is critical: particles below 100 nm are cleared too rapidly by the renal system, while particles above 300 nm face significant physical barriers to intestinal absorption

Globally, Croton species have been traditionally used to treat HTN and edema-related conditions (275, 276)

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Because this area has a rich blood supply but is less vascular than muscle, allowing for a slower, more sustained release and absorption of the peptide into the systemic circulation

doi: 10.1038/ni.2556 115 KonoMYoshidaNMaedaKTsokosGC

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