Statements Acknowledgments We apologize for not being able to cite many relevant original papers, replaced by reviews, due to space limitation
In line with the intracellular contributions to these clinical findings, correlation of intraepithelial cell GSH levels to FEV 1 was considerably stronger than the relationship in BAL fluid, supporting the overall importance of endogenous epithelial cell responses to clinical outcomes
In particular, the initial burst of superoxide that cannot be eliminated efficiently due to the inactivity of SOD1 is promptly buffered by the induction of GSH synthesis resulting in protection against oxidative stress and cell death
Sakr, H
36 The induction of MPTP will eventually cause the release of multiple important mitochondrial proteins into the cytoplasm, such as apoptosis-inducing factor (AIF), endonuclease G (Endo G), and cytochrome c (Cyt C)
It helps to hold the water in the skin, which keeps it fresh and hydrated