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Although many pathological stimuli can trigger necroptosis, the most typical pathway for inducing necroptosis is TNF and FAS signaling, in which CASP8 inhibition activates necrosomes (a multi-protein complex containing RIPK1, RIPK3, and MLKL) to trigger necroptosis [113]

Hashimoto Y, Kurita M, Aiso S et al (2009) Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor /WSX-1/gp130

Antioxidant alternatives in the treatment of amyotrophic lateral sclerosis: a comprehensive review

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Tani et al., 2018)

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