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For instance, a taxon with low abundance might be highly metabolically active and produce significant amounts of biologically relevant metabolites (e.g., SCFAs), whereas a highly abundant taxon could be in a quiescent state

Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]