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doi: 10.1371/journal.pone.0074223

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Metabolic profiling studies did not reveal an obvious metabolic explanation for the results, although markedly lower levels of one of hydroxylated metabolites (3-hydroxyacetyl- para -aminophenol

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Overall, ROS accumulation in conjunction with declining antioxidant defenses may contribute to oocyte and granulosa cell dysfunction and influence the aging trajectory of the follicular microenvironment