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(2013) studied serum from 22 FM patients compared with 22 healthy female controls and identified significant alterations in purine metabolism, specifically decreased levels of adenosine, a precursor for ATP synthesis

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Heikkil, O., Nygrdas, M., Paavilainen, H., Rydi, E

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Not only does improving sleep improve GI function, but improving GI health also improves sleep.[60] A poor sleep-wake cycle triggers inflammatory cytokines that can exacerbate inflammatory bowel disease (IBD) and disrupt GI immunity.[61] Poor sleep can also result in lower melatonin levels