In particular, they pointed out that although NRF2 has been traditionally considered as a tumor suppressor because of its cytoprotective functions [320], a growing number of studies have shown a strong NRF2 activation at certain stages of cancer [318, 321]
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One specific study found that 7 out of 12 clinical patients suffering from chronic knee pain reported improvement and relief that lasted more than six months
Factors that may disrupt healthy estrogen detoxification include alcohol, insulin resistance, obesity, oral contraceptives, and HRT
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