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Once anesthetized, the right knee joints of the animals were shaved, sterilized, and subjected to an intra-articular injection of collagenase type II

Patients experiencing adverse reactions are encouraged to contact their healthcare provider promptly

AOD-9604 is an intellectually interesting compound whose mechanism is well-characterized in preclinical models, whose safety profile is genuinely clean, and whose clinical program ultimately did not deliver

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This level of documentation is essential for reproducibility in published research and for audit trails at institutional laboratories

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