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El-Hattab, AW, Adesina, AM, Jones, J, Scaglia, F 2015, MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options, Molecular genetics and metabolism , vol

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Conversely, enriching the gut microbiota with fiber-fermenting bacteria increases SCFA production and has protective effects: SCFAs signal through receptors like GPR43/GPR109A on immune cells to suppress NF-B activation and induce Tregs [70]

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These results also suggest that administration of amoxicillin-clavulanic acid induced reproducible taxon relative abundance changes on microbiota composition, as well as exhibiting transient perturbations, as shown in both placebo and probiotic arms (Fig