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ATM inhibition drives metabolic adaptation via induction of macropinocytosis

Chronic hypoxia is common in life and includes environmental hypoxia, such as altitude exposure, and hypoxia of the body or organs during aging and disease [21]

Across treatment groups, most participants had their first gastrointestinal disorders within 46 weeks after starting treatment

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The human glutathione S-transferases: developmental aspects of the GST1, GST2, and GST3 loci

In other words, the preclinical signal appears against a backdrop of controlled energy intake and activity, not as a standalone effect that overrides diet