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High levels of oxidative stress may contribute to ALS onset, increasing motoneurons death, and heavy metals may be a cause for the increase of ROS

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The early phase of the infection is associated with a mixed Type 1/Type 2 immune response which peaks 7 days post-infection (dpi) [38, 39]

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doi:10.1016/j.ejrad.2021.109722

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The 2-Cys PRX proteins are glutathionylated by GSSG, a process that favours dimerization and inactivates their molecular chaperone activities (Park et al

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therefore, they react at their generation site (102, 103)

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