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Compared to use of a placebo (84 patients) in this trial, use of -tocopherol (85 patients) significantly slowed progression of Alzheimer's dementia, evidenced by significant improvements on the Blessed Dementia Scale and time to institutionalization (122)

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It is abundant in secretory cells of the intestine and pancreas, co-existing with pancreatic polypeptide

177,178 This may be a consequence of the very slow off-rate of bound Zn II in this inhibited complex, relative to the more weakly bound Mn II which upon engagement of the transmembrane domain readily releases Mn II into the transport channel

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