However, adverse effects may limit the treatment potential, e.g., glitazones are associated with phenotypical weight gain [136] and obeticholic acid induced pruritus and elevated LDL-C [137], the latter a potential concern in patients already at risk for cardiovascular disease
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Here we describe some of the most characterized examples: Ethacrynic acid and analogues Ethacrynic acid (EA)an ,-unsaturated ketone used as diuretic drugis a common substrate/inhibitor of several GSTs (Fig
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Possible mild side effects: Temporary redness at the injection site Mild discomfort Rare allergic reactions Choosing a reputable clinic significantly minimizes risks
Over-the-counter enemas are likely a safer option