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Compound W478 binds to SHMT2 at its folate binding site, suggesting its potential as a highly effective lead compound for the synthesis of SHMT2 inhibitors, which may lead to new treatment options for esophageal cancer [163]

Hormonal fluctuations, particularly in females, can affect ligament laxity and susceptibility to injury, as variations in estrogen levels have been linked to changes in the mechanical properties of the ACL

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