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Third, adaptive clinical trial designs involving larger patient cohorts and multi-center validation will be crucial to demonstrate efficacy beyond preclinical promise

Rather than aiming for broad use across all solid tumors, TME-oriented nanoplatforms may find their place in more narrowly defined subgroups where they can deliver sufficient incremental benefit to justify their complexity

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In summary, these results establish a nonmetabolic syndrome, immuneredox lipid-remodeling phenotype in IMDD that involves the NIMETOX pathway and contributes to the severity, stage, and progression of the disease [235, 236]

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