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The representativeness of trials resulting in an FDA approval has been gradually improving in several dimensions since 2014

Genetically encoded fluorescent indicator for imaging NAD(+)/NADH ratio changes in different cellular compartments

doi: 10.1016/j.pt.2013.01.003 84 HuYSunLYuanZXuYCaoJ

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Small historical studies investigated healthy volunteers, chronic insomnia, narcolepsy, withdrawal and pain