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In some embodiments, the otic formulation or composition comprises about 25% by weight of the poloxamer

Biochemical and omics biomarkers in cognition Classical CSF and plasma biomarkers A40 / A42 (important ratio in amyloid pathology) Total tau / p-tau181 / p-tau217 (tauopathic markers) Neurofilament light (NfL) : axonal degeneration marker GFAP : astrocytic activation BDNF and pro-BDNF : neurotrophic activity IL-6, TNF, IL-1 : neuroinflammation Transcriptomics and epigenomics Hippocampal RNA-seq after chronic administration of Semax or Selank often reveals a neurotrophic activation signature (BDNF, NT3, NGF, NR4A1-3) coupled with anti-inflammatory modulation (NF-B targets down)

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Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that cluster 1 (1,747 nuclei) expressed genes involved in fatty acid metabolism, phosphatidylinositol-3-kinase (PI3K)-AKT signalling and lipolysis

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A third GGT, called GGT4 (At4g29210), originally called GGT3 by Ohkamu-Ohtsu et al