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Many pharmaceutical companies have tried to develop drugs that target Mcl-1, but this has been difficult because the interaction between Mcl-1 and its target protein occurs in a long stretch of 20 to 25 amino acids, which is difficult to block with the small molecules typically used as drugs

Azathioprine or 6-MP can be considered, but usually neither is recommended for induction therapy because the data on efficacy are limited and the onset of action is slow

The strongest approach for broad healing research may be combining both

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