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Patients with liver disease, abnormal liver function, known glutathione allergy, or those who are pregnant or breastfeeding should not receive IV glutathione

Cancer Cell 22 , 631644 (2012)

Acta Pharmacol Sin 26:10091016

The solution is not to increase the dose prematurely

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At 37 C, the translation efficiency of FLuc mRNA modified with hm 5 C, hm 5 C + 5moU, and hm 5 C + m 1 reached 0.3, 0.5, and 0.9, respectively, while the hm 5 C + m 5 U combination was 2-fold more efficient than unmodified mRNA