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doi: 10.3389/fphar.2022.977385 Received 24 June 2022 Accepted 01 September 2022 Published 27 September 2022 Volume 13 - 2022 Edited by Sai Wang Seto, Hong Kong Polytechnic University, Hong Kong SAR, China Reviewed by Dominic Del Re, The State University of New Jersey, United States Karen R

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-Synuclein interferes with synaptic vesicle trafficking, mitochondrial dynamics, and axonal transport, ultimately leading to synaptic dysfunction, impaired neurotransmission, and axonopathy

Clinical literature references loading phases, maintenance phases, and cycle durations that vary by provider and patient profile