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Bifidobacterium was significantly enriched in T2 and T3 (23.67% 6.46% and 30.96% 7.2%) compared to T1(17.77% 9.37%

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AOX: antioxidant, MDA: malondialdehyde acid, ORP: oxidation-reduction potential, RCT: randomized controlled trial, SDF: sperm DNA fragmentation, TAC: total antioxidant capacity

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No GI breakdown Consistent systemic delivery SQ or IM administration 1

2.2.3 Cholesterol metabolism in HCC Given the low expression of low-density lipoprotein receptor (LDLR), the transmembrane receptor for cholesterol, facilitates upregulated cholesterol synthesis, the expression of LDLR seems to be notably lower than that in normal cells surrounding the tumor in HCC (Chen et al., 2021)