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The safety of curcumin supplementation in CKD patients warrants careful consideration, particularly due to its dose-dependent adverse effects and potential for drug interactions, especially with medications possessing narrow therapeutic windows or those metabolized by CYP enzymes and P-gp

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Among the identified metabolites, only Ac-LKKTE exhibited in vitro wound healing activity, indicating that previous functional effects attributed to TB-500 may be due to this specific metabolite (Rahaman et al