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Normal cells, which do not rely on FOXO4-p53 binding for survival, are unaffected

This means the molecule draws water from the body into the bowel to help flush the "excess" material out, resulting in watery or loose stools

Hirschenson et al

Current reviews in clinical and experimental pharmacology, 16(2), 162167

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However, the peptide binds to extracellular matrix proteins in connective tissue and wound healing effects persist 714 days after a single dose, indicating tissue depot retention beyond systemic clearance