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Third, it upregulates VEGFR2 and activates the VEGFR2-Akt-eNOS pathway, accelerating blood vessel formation and blood flow recovery in ischaemic tissue, a mechanism confirmed in endothelial cell culture and rat hind-limb ischaemia models by Hsieh 2017

Following a 12 h incubation period, the 143B cells were incubated with PBS, Ru(II)-OH, NP2, or NP4 (10 M Ru) for 6 h

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