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The primary objective of this research is to elucidate the mechanisms underlying the glucose-lowering and metabolic effects of semaglutide

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Hornsby AK, Redhead YT, Rees DJ, Ratcliff MS, Reichenbach A, Wells T, Francis L, Amstalden K, Andrews ZB, and Davies JS

& Samulski, R

Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-B signaling pathway in mice spinal cords

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The downstream effects of RAGE-induced ROS in rat mesangial cells include reduced levels of the antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) (50) and increased activation of phosphoinositide 3-kinase (PI3K)/AKT pathway, which leads to activation of nuclear factor (NF)-B and the production of pro-inflammatory cytokines (51)