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This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance

This rebound effect occurs because the amylin receptor system, having adapted to sustained agonism, temporarily overcompensates when that stimulation is removed

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[Google Scholar] 74.Phang JM, Liu W, Hancock CN, Fischer JW

When stacked together, these discounts can lower the per-serving cost to approximately $0.30