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No significant changes were detected in the expression of classical thermogenic genes ( Ucp1 , Dio2 , Prdm16 ), creatine metabolism genes ( Ckmt1 , Ckmt2 ), or calcium cycling regulators ( Atp2a2 , Ryr1 , Ryr2 ) in BAT, eWAT, or iWAT (Supplementary Fig

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In humans, cardioprotective effects are partly attributed to reduced myocardial autophagy and apoptosis via the AMPK/mTOR pathway (26)