In this study, our results suggested that the core targets among riboflavin, osteogenesis and osteoclastogenesis included HIF1A, HDAC2/3/4, TP53, PPARG, PPARGC1A, NFKB1, MYC and BCL2, and the potential signaling pathways of vitamin B2 involved in regulating bone health focused on HIF-1 signaling pathway, p53 signaling pathway, AGE-RAGE signaling pathway, longevity regulating pathway, and so on
Increased risk of chronic diseases: Low glutathione is associated with cardiovascular disease, neurodegenerative conditions, and cancer
Habibalahi et al, 2022) and others (Huang et al, 2022
new roles of Notch signaling
Most nanosystems for the treatment of solid tumors are administered systemically and accumulated in the tumor tissues through the enhanced permeability and retention (EPR) effect, which is generally thought to be the result of leaky tumor vasculature and poor lymphatic drainage (Maeda, 2015)
The progression of diseases associated with metabolic syndrome occurs through a range of dynamic changes within the vasculature ( This review highlights the prevalence, molecular mechanisms and combating approaches of underlying risk conditions by managing endothelial dysfunction, hypertension, and platelet hyperactivity/prothrombotic state with bioactive compounds like polyphenols, small molecules like miRNA, and gene therapy